The important derivatives of 2-trifluoroethoxy benzoic acid production method are niacin, niacinamide, iso-niacinamide, nicotine, brucine, vitamin B6 and so on. 2-trifluoroethoxy benzoic acid production method has a nearly regular hexagonal structure, similar to benzene, with the same electronic structure.
Due to the electron-absorbing effect of nitrogen atoms in the ring, the density of electron clouds at 2,4 and 6 sites is lower than that at 3 and 5 sites. In acidic media, electrophilic substitution reactions occur at 3 and 5 sites, while nucleophilic reactions such as amination, alkylation, arylation and acylation occur at 2,4 and 6 sites. 2-trifluoroethoxy benzoic acid production method is a kind of weak tertiary amine, in ethanol solution can with a variety of acids (such as picric acid, perchloric acid, etc.) to form insoluble salt.
2-trifluoroethoxy benzoic acid production method is alkaline and can be used to produce 2-trifluoroethoxy benzoic acid production method. Piperidine can be produced by hydroreduction under the action of nickel catalyst at 200℃ and 15~30MPa. It can also be electrolytically reduced to piperidine; It is easier to reduce than benzene.
2-trifluoroethoxy benzoic acid production method 2- Trifluoroethoxy benzoic acid production method 2-trifluoroethoxy benzoic acid production method, 2-trifluoroethoxy benzoic acid production method, 2- Trifluoroethoxy benzoic acid production method, This is an important 2-trifluoroethoxy benzoic acid production method derivatives, due to the oxidation of nitrogen atoms, 2-trifluoroethoxy benzoic acid production method ions cannot be formed with positive charge, which is advantageous for the electrophilic substitution of aryl groups.
The electrophilic replacement of 2-trifluoroethoxy benzoic acid production method, such as nitrification, sulfonation and halogenation are difficult, but halogenation is slightly easier than the first two, above 200℃, 3, 5-dichloro2-trifluoroethoxy benzoic acid production method, or 3,4.5- 2-trifluoroethoxy benzoic acid production method is obtained. 2-trifluoroethoxy benzoic acid production method can be used to form crystalline coordination compounds with various metal ions.
2-trifluoroethoxy benzoic acid production method https://www.clentpharma.com/Preparation-of-2-5-bis-2-2-2-trifluoroethoxy-benzoic-acid.html
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