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For a number of reasons, people with significant liver impairment are generally not advised to take Zudena Pills, which contain the PDE5 inhibitor sildenafil. Sildenafil Metabolism: The liver is where sildenafil is mostly broken down. The capacity of the liver to metabolize drugs is greatly diminished in people with severe liver impairment. Higher blood levels of Zudena Pills may result from this, raising the possibility of adverse effects and possible toxicity.
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