Syphilis Is Evolving Like Never Before.. In Michigan

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These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:

A Cluster of Ocular Syphilis Cases with a Common Partner — Southwest Michigan, 2022: https://www.cdc.gov/mmwr/volumes/72/wr/mm7247a1.htm

Initial Ocular Syphilis Cases: https://www.cdc.gov/mmwr/volumes/65/wr/mm6543a2.htm

CDC issues guidance about ocular syphilis (related to Seattle 2015 cases) https://www.cdc.gov/mmwr/volumes/65/wr/mm6543a2.htm

Complete genome sequence of Treponema pallidum, the syphilis spirochete. https://pubmed.ncbi.nlm.nih.gov/9665876/

Molecular Typing of Treponema pallidum in Ocular Syphilis. https://pubmed.ncbi.nlm.nih.gov/27419819/

Rising Incidence of Syphilitic Uveitis–Related Hospitalizations in the US https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2812271

Incidence and Prevalence of Ocular Syphilis and Associated Ocular Complications in the TriNetX Database https://iovs.arvojournals.org/article.aspx?articleid=2807099

Disseminated Syphilis Caused by Two Recombining Treponema pallidum Strains. https://www.nejm.org/doi/full/10.1056/NEJMc2500231